AA74-1

SIGMA/SML0358 - ≥98% (HPLC)

Synonym: [4-(4-Hydroxy-2,6-dimethylheptan-4-yl)-2H-1,2,3-triazol-2-yl](pyrrolidin-1-yl)methanone; [4-[1-Hydroxy-3-methyl-1-(2-methylpropyl)butyl]-2H-1,2,3-triazol-2-yl]-1-pyrrolidinylmethanone

CAS Number: 1361532-00-4
Empirical Formula (Hill Notation): C₁₆H₂₈N₄O₂
Molecular Weight: 308.42
MDL Number: MFCD23704789
Linear Formula: C₁₆H₂₈N₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0358-5MG	5 mg	$207.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	colorless
form	film
InChI	1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3
InChI key	GXBVPGCIMCIASQ-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2
solubility	DMSO: >15 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:

AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC₅₀ of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells.

The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity.

Packaging:

5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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