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NPS2143 hydrochloride

SIGMA/SML0362 - ≥98% (HPLC)

Synonym: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1); NPS-2143 hydrochloride; SB-262470-A hydrochloride

CAS Number: 324523-20-8
Empirical Formula (Hill Notation): C24H25ClN2O2 · HCl
Molecular Weight: 445.38
MDL Number: MFCD16038896
Linear Formula: C24H25ClN2O2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0362-5MG 5 mg
 $162.00
1/EA		 Add To Favorites
45-SML0362-25MG 25 mg
 $649.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key ZEBNDUQLNGYBNL-VEIFNGETSA-N
optical activity [α]20/D +20 to +24°, c = 1.0 in methanol
Quality Level 100 
SMILES string Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
solubility DMSO: >10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :
• In the regulation of intestinal calcium transport.
• In the regulation of local negative feedback of intestinal calcium absorption.
• In sensorimotor decision making during development.
Biochem/physiol Actions: NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
Biochem/physiol Actions: NPS2143 is a selective calcium-sensing receptor (CaR) antagonist.
Biochem/physiol Actions: NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50 of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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