NPS2143 hydrochloride

SIGMA/SML0362 - ≥98% (HPLC)

Synonym: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1); NPS-2143 hydrochloride; SB-262470-A hydrochloride

CAS Number: 324523-20-8
Empirical Formula (Hill Notation): C₂₄H₂₅ClN₂O₂ · HCl
Molecular Weight: 445.38
MDL Number: MFCD16038896
Linear Formula: C₂₄H₂₅ClN₂O₂ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0362-5MG	5 mg	$158.00 1/EA	Add To Favorites
45-SML0362-25MG	25 mg	$631.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key	ZEBNDUQLNGYBNL-VEIFNGETSA-N
optical activity	[α]20/D +20 to +24°, c = 1.0 in methanol
Quality Level	100
SMILES string	Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
solubility	DMSO: >10 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor : • In the regulation of intestinal calcium transport. • In the regulation of local negative feedback of intestinal calcium absorption. • In sensorimotor decision making during development.
Biochem/physiol Actions:	NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
Biochem/physiol Actions:	NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 + H312 + H332 - H410
Precautionary statements	P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Codes	Xn,N
Risk Statements	20/21/22-50/53
Safety Statements	36/37-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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