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RAD51 Inhibitor B02

SIGMA/SML0364 - ≥98% (HPLC)

Synonym: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

CAS Number: 1290541-46-6
Empirical Formula (Hill Notation): C22H17N3O
Molecular Weight: 339.39
MDL Number: MFCD03294274
Linear Formula: C22H17N3O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0364-5MG 5 mg
 $170.00
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45-SML0364-25MG 25 mg
 $649.00
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assay ≥98% (HPLC)
color white to dark brown
form powder
InChI 1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
InChI key GEKDQXSPTHHANP-OUKQBFOZSA-N
Quality Level 100 
SMILES string O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
solubility DMSO: ≥5 mg/mL
storage temp. 2-8°C
Application: RAD51 Inhibitor B02 has been used:
• to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
• for RAD51 inhibition in porcine embryos
• as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)
Biochem/physiol Actions: B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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