RAD51 Inhibitor B02

SIGMA/SML0364 - ≥98% (HPLC)

Synonym: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

CAS Number: 1290541-46-6
Empirical Formula (Hill Notation): C₂₂H₁₇N₃O
Molecular Weight: 339.39
MDL Number: MFCD03294274
Linear Formula: C₂₂H₁₇N₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0364-5MG	5 mg	$158.00 1/EA		Add To Favorites
45-SML0364-25MG	25 mg	$631.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to dark brown
form	powder
InChI	1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
InChI key	GEKDQXSPTHHANP-OUKQBFOZSA-N
Quality Level	100
SMILES string	O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
solubility	DMSO: ≥5 mg/mL
storage temp.	2-8°C

Application:	RAD51 Inhibitor B02 has been used: • to test its effect on the polar body extrusion (PBE) rate in porcine oocytes • for RAD51 inhibition in porcine embryos • as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)
Biochem/physiol Actions:	B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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