NSC23925
SIGMA/SML0372 - ≥98% (HPLC)
Synonym: 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride; NSC-23925; [2-
CAS Number: 858474-14-3
Empirical Formula (Hill Notation): C22H24N2O2 · 2HCl
Molecular Weight: 421.36
MDL Number: MFCD22666390
Linear Formula: C22H24N2O2 · 2HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C22H24N2O2.2ClH/c1-26- |
| InChI key | WGWOQHWZXLGPNG-UHFFFAOYSA |
| Quality Level | 100 ![]() |
| SMILES string | Cl.Cl.COc1ccc(cc1)-c2cc(C |
| solubility | H2O: 5 mg/mL (clear solution) |
| storage condition | desiccated |
| storage temp. | room temp |
| Biochem/physiol Actions: | NSC23925 is a specific Pgp1 inhibitor. |
| Biochem/physiol Actions: | NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol | GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12161501 |


