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NSC23925

SIGMA/SML0372 - ≥98% (HPLC)

Synonym: 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride; NSC-23925; [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride

CAS Number: 858474-14-3
Empirical Formula (Hill Notation): C22H24N2O2 · 2HCl
Molecular Weight: 421.36
MDL Number: MFCD22666390
Linear Formula: C22H24N2O2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0372-25MG 25 mg
 $404.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
InChI key WGWOQHWZXLGPNG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2
solubility H2O: 5 mg/mL (clear solution)
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12161501

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