KU 0063794
SIGMA/SML0382 - ≥98% (HPLC)
Synonym: rel-
CAS Number: 938440-64-3
Empirical Formula (Hill Notation): C25H31N5O4
Molecular Weight: 465.54
MDL Number: MFCD11977741
Linear Formula: C25H31N5O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C25H31N5O4/c1-16-13-30 |
| InChI key | RFSMUFRPPYDYRD-CALCHBBNSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(cc1CO)-c2ccc3c(nc |
| solubility | DMSO: >2 mg/mL (warmed) |
| storage temp. | 2-8°C |
| Application: | KU 0063794 has been used: • as a mammalian target of rapamycin (mTOR) inhibitor to study the effects of follicular stimulating hormone (FSH) in mTOR phosphorylation and vascular cell adhesion molecule-1 (VCAM-1) expression in human umbilical vascular endothelial cells (HUVECs) • as a mTOR inhibitor to treat effector memory (EM) CD8+ T cells for metabolic flux analysis • as an autophagy inducer to demonstrate the utility of p62 and LC3B-II quantification in HEK293T cells and primary cultures of rat neurons and astrocytes using time-resolved fluorescence resonance energy transfer (TR-FRET) |
| Biochem/physiol Actions: | KU 0063794 induces autophagy. It is cell-permeant and suppresses activation and hydrophobic motif phosphorylation of protein kinase B (Akt), p70 ribosomal S6 kinase (S6K) and serum and glucocorticoid protein kinase (SGK). |
| Biochem/physiol Actions: | KU 0063794 is a potent and selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for both mTORC1 and mTORC2) that inhibits both mTORC1 and mTORC2 in vitro and in vivo (IC50 ~10 nM for both mTORC1 and mTORC2). KU 0063794 does not significantly inhibit 76 other protein kinases tested as well as seven lipid kinases including PI3K and AKT. |
| Biochem/physiol Actions: | KU 0063794 is a potent and selective inhibitor of mammalian target of rapamycin (mTOR); inhibits both mTORC1 and mTORC2 in vitro and in vivo. |
| Features and Benefits: | This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |