ML218
SIGMA/SML0385 - ≥98% (HPLC)
Synonym: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]benzamide; CID 45115620; VU0413807; VU0424199-1
CAS Number: 1346233-68-8
Empirical Formula (Hill Notation): C19H26Cl2N2O
Molecular Weight: 369.33
Linear Formula: C19H26Cl2N2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H26Cl2N2O/c1-19(2,3 |
InChI key | GSJIGYLGKSBYBC-OSYLJGHBSA |
Quality Level | 100 ![]() |
SMILES string | CC(C)(C)CCN1C[C@H]2C(CNC( |
solubility | DMSO: 10 mg/mL (clear solution) |
storage temp. | 2-8°C |
Application: | ML218 has been used as a: • T-type channel blocker to test its effect on the nociceptive behavior associated with homocysteinemia rats • T-type voltage-sensitive calcium channel (VSCC) inhibitor in osteoblasts • T-type calcium channel blocker to test its effect on the viability of neural progenitor cells |
Biochem/physiol Actions: | ML218 (CID 45115620) is a potent and selective T-Type (Cav3.1, Cav3.2, Cav3.3) calcium channel inhibitor (Cav3.2, IC50 = 150 nM in Ca2+ flux; Cav3.2 IC50 = 310 nM and Cav3.3 IC50 = 270 nM with good Drug metabolism/Pharmacokineti |
Features and Benefits: | This compound is featured on the Calcium Channels ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |