QNZ46

SIGMA/SML0393 - ≥98% (HPLC)

Synonym: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid

CAS Number: 1237744-13-6
Empirical Formula (Hill Notation): C₂₄H₁₇N₃O₆
Molecular Weight: 443.41
MDL Number: MFCD22666391
Linear Formula: C₂₄H₁₇N₃O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0393-5MG	5 mg	$119.00 1/EA	Add To Favorites
45-SML0393-25MG	25 mg	$472.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
InChI key	GNLVJIICVWDSNI-LFYBBSHMSA-N
Quality Level	100
SMILES string	COc1ccc2N=C(C=Cc3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
solubility	DMSO: 5 mg/mL (warmed; clear solution)
storage temp.	room temp

Biochem/physiol Actions:	QNZ46 is a noncompetitive inhibitor of GluN2C/D (NMDA antagonist).
Biochem/physiol Actions:	QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC₅₀ values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.
Features and Benefits:	This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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