Synonym: (R,S)-Salsolinol hydrobromide; 1,2,3,4-Tetrahydro-1-methylisoquinoline-6,7-diol hydrobromide; 1-Methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide; 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 1,2,3,4-Tetrahydro-1-methylisoquinoline-6,7-diol hydrobromide; 1-Methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide
CAS Number: 59709-57-8
Empirical Formula (Hill Notation): C10H13NO2 · HBr
Molecular Weight: 260.13
MDL Number: MFCD00012741
Linear Formula: C10H13NO2 · HBr
Product Type: Chemical
| assay |
≥96% (HPLC) |
| color |
white to brown |
| form |
powder |
| InChI |
1S/C10H13NO2.BrH/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6;/h4-6,11-13H,2-3H2,1H3;1H |
| InChI key |
OGMGXKJQIOUTTB-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Br.CC1NCCc2cc(O)c(O)cc12 |
| solubility |
H2O: 5 mg/mL (warmed; clear solution) |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Salsolinol is the condensation product of acetaldehyde and dopamine. Salsolinol is a potential neurotoxin suspected to contribute to alcohol abuse. It appears that salsolinol excites the ventral tegmental area (VTA) dopamine neurons indirectly by activating μ-opioid receptors (MORs), which inhibit GABA neurons in the VTA. |
| Biochem/physiol Actions: |
Salsolinol, a neurotoxin, can serve as a prolactin-releasing factor and an etiological factor in the tuberoinfundibular pathway and in Parkinson′s disease (PD), respectively. It can also act as a modulator of catecholaminergic neurotransmission in the nigrostriatal pathway. In central nervous system, salsolinol can change the role of dopaminergic neurons and dopamine metabolism. |
| Features and Benefits: |
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: |
Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) is present in various edibles. It is available as R and S enantiomers. R-salsolinol in predominantly found in the brain tissue of humans. |
| Packaging: |
10, 50 mg in glass bottle |
| Purity |
≥96% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
GHS07