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D,L-Metanephrine hydrochloride

SIGMA/SML0399 - ≥98% (HPLC)

Synonym: (±)-Metanephrine hydrochloride; 4-Hydroxy-3-methoxy-a-[(methylamino)methyl]-benzenemethanol hydrochloride; DL-3-O-Methyladrenaline hydrochloride; DL-Metanephrine hydrochloride; Metadrenaline hydrochloride; dl-Metanephrine hydrochloride; m-O-Methyladrenaline hydrochloride

CAS Number: 881-95-8
Empirical Formula (Hill Notation): C10H15NO3 · HCl
Molecular Weight: 233.69
EC Number: 212-922-2
MDL Number: MFCD00012487
Linear Formula: C10H15NO3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0399-10MG 10 mg
 $155.00
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45-SML0399-50MG 50 mg
 $613.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C10H15NO3.ClH/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2;/h3-5,9,11-13H,6H2,1-2H3;1H
InChI key HRIQFVCFOPJYEQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC1=C(OC)C=C(C(CNC)O)C=C1.Cl
solubility H2O: 12 mg/mL (clear solution)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Metanephrine is an endogenous metabolite of ephinephrine, formed by catechol-O-methyl transferase activity. It is best known as a biomarker for cancers, as levels of free metanephrine are used to diagnose pheochromocytoma. Metanephrine was previously thought to be biologically inactive, but it is a more potent agonist at Trace amine associated receptor TAAR1 than either epinephrine or norepinephrine. Trace amine associated receptors (TAARs) are recently discovered GPCRs that are activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). Trace amines and TAARs are expressed in brain and are implicated in modulation of monoaminergic neurotransmission.
Features and Benefits: This compound is featured on the Dopamine and Norepinephrine Metabolism  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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