ML 141

SIGMA/SML0407 - ≥98% (HPLC)

Synonym: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

CAS Number: 71203-35-5
Empirical Formula (Hill Notation): C₂₂H₂₁N₃O₃S
Molecular Weight: 407.49
MDL Number: MFCD05987165
Linear Formula: C₂₂H₂₁N₃O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0407-5MG	5 mg	$127.00 1/EA	Add To Favorites
45-SML0407-25MG	25 mg	$505.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
InChI key	QBNZBMVRFYREHK-UHFFFAOYSA-N
Quality Level	100
SMILES string	NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O
solubility	DMSO: 5 mg/mL (warmed, clear solution)
storage temp.	2-8°C

Application:	ML 141 has been used: • to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells • as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei • as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria • as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
Biochem/physiol Actions:	ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC₅₀ for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

To Order From a Quote