ML 141
SIGMA/SML0407 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 71203-35-5
Empirical Formula (Hill Notation): C22H21N3O3S
Molecular Weight: 407.49
MDL Number: MFCD05987165
Linear Formula: C22H21N3O3S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C22H21N3O3S/c1-28-19-1 |
InChI key | QBNZBMVRFYREHK-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | NS(C1=CC=C(C=C1)N2N=C(C3= |
solubility | DMSO: 5 mg/mL (warmed, clear solution) |
storage temp. | 2-8°C |
Application: | ML 141 has been used: • to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells • as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei • as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria • as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells |
Biochem/physiol Actions: | ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking. |
Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here ![]() ![]() |
Features and Benefits: | This compound is featured on the GTP Binding Proteins (Low Molecular Weight) ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |