STF-083010
SIGMA/SML0409 - ≥98% (HPLC)
Synonym: N-
CAS Number: 307543-71-1
Empirical Formula (Hill Notation): C15H11NO3S2
Molecular Weight: 317.38
MDL Number: MFCD02332975
Linear Formula: C15H11NO3S2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | light yellow to yellow-green |
| form | powder |
| InChI | 1S/C15H11NO3S2/c17-14-8-7 |
| InChI key | TVIVJHZHPKNDAQ-MHWRWJLKSA |
| Quality Level | 100  |
| SMILES string | OC1=C(/C=N/S(C2=CC=CS2)(= |
| solubility | DMSO: 5 mg/mL (clear solution) |
| storage temp. | −20°C |
| Application: | STF-083010 has been used: • in a study to investigate the potential anti-lipoto • as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes • to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity |
| Biochem/physiol Actions: | STF-083010 is a potent inhibitor of IRE-1 mRNA splicing activity. |
| Biochem/physiol Actions: | STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |