FQI1

SIGMA/SML0413 - ≥98% (HPLC)

Synonym: 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one

CAS Number: 599151-35-6
Empirical Formula (Hill Notation): C₁₈H₁₇NO₄
Molecular Weight: 311.33
MDL Number: MFCD03632583
Linear Formula: C₁₈H₁₇NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0413-5MG	5 mg	$119.00 1/EA		Add To Favorites
45-SML0413-25MG	25 mg	$472.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
InChI key	YKSYGLXHLSPWLB-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1
solubility	DMSO: 10 mg/mL (clear solution)
storage temp.	2-8°C

Biochem/physiol Actions:	FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.
Biochem/physiol Actions:	FQI1 is an inhibitor of transcription factor LSF.
Packaging:	5, 25 mg in glass bottle

Hazard Codes	T,N
Risk Statements	25-50
Safety Statements	45-61
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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