FQI1
SIGMA/SML0413 - ≥98% (HPLC)
Synonym: 8-
CAS Number: 599151-35-6
Empirical Formula (Hill Notation): C18H17NO4
Molecular Weight: 311.33
MDL Number: MFCD03632583
Linear Formula: C18H17NO4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C18H17NO4/c1-2-21-15-6 |
InChI key | YKSYGLXHLSPWLB-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | O=C1CC(C2=CC=CC=C2OCC)C3= |
solubility | DMSO: 10 mg/mL (clear solution) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model. |
Packaging: | 5, 25 mg in glass bottle |
Hazard Codes | T,N |
Risk Statements | 25-50 |
Safety Statements | 45-61 |
RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |