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FQI1

SIGMA/SML0413 - ≥98% (HPLC)

Synonym: 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one

CAS Number: 599151-35-6
Empirical Formula (Hill Notation): C18H17NO4
Molecular Weight: 311.33
MDL Number: MFCD03632583
Linear Formula: C18H17NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0413-25MG 25 mg
 $472.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
InChI key YKSYGLXHLSPWLB-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1
solubility DMSO: 10 mg/mL (clear solution)
storage temp. 2-8°C
Biochem/physiol Actions: FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.
Biochem/physiol Actions: FQI1 is an inhibitor of transcription factor LSF.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T,N
Risk Statements 25-50
Safety Statements 45-61
RIDADR UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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