NCX 4040

SIGMA/SML0414 - ≥98% (HPLC)

Synonym: 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester; NO-aspirin

CAS Number: 287118-97-2
Empirical Formula (Hill Notation): C₁₆H₁₃NO₇
Molecular Weight: 331.28
MDL Number: MFCD08062164
Linear Formula: C₁₆H₁₃NO₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0414-5MG	5 mg	$121.00 1/EA		Add To Favorites
45-SML0414-25MG	25 mg	$331.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H13NO7/c1-11(18)23-15-5-3-2-4-14(15)16(19)24-13-8-6-12(7-9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChI key	CTHNKWFUDCMLIQ-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC(=O)Oc1ccccc1C(=O)Oc2ccc(CO[N+]([O-])=O)cc2
solubility	DMSO: 15 mg/mL (clear solution)
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	NCX 4040 is a nitric oxide-donating form of aspirin.
Biochem/physiol Actions:	NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.
Features and Benefits:	This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H317 - H318 - H400
Precautionary statements	P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310
Hazard Codes	Xi
Risk Statements	41-43
Safety Statements	26-36/37-39
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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