Alantolactone
SIGMA/SML0415 - ≥98% (HPLC)
Synonym: (+)-Alantolactone.; 3aR,5S,8aR,9aR)
CAS Number: 546-43-0
Empirical Formula (Hill Notation): C15H20O2
Molecular Weight: 232.32
EC Number: 208-899-3
MDL Number: MFCD00274568
Linear Formula: C15H20O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H20O2/c1-9-5-4-6-15 |
| InChI key | PXOYOCNNSUAQNS-AGNJHWRGSA |
| Quality Level | 100  |
| SMILES string | C[C@H]1CCC[C@]2(C)C[C@H]3 |
| solubility | DMSO: 15 mg/mL (clear solution) |
| storage condition | desiccated |
| protect from light | |
| storage temp. | −20°C |
| Application: | Alantolactone has been used: • in cell viability assay • to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC) • in assessment of degranulation |
| Biochem/physiol Actions: | Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells. |
| Biochem/physiol Actions: | Alantolactone is an inducer of activin/SMAD3 signaling. |
| General description: | Alantolactone is a compound produced by Inula helenium. Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261 - P272 - P280 - P333 + P313 - P362 + P364 - P501 |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |