TCN-201
SIGMA/SML0416 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 852918-02-6
Empirical Formula (Hill Notation): C21H17ClFN3O4S
Molecular Weight: 461.89
MDL Number: MFCD06683895
Linear Formula: C21H17ClFN3O4S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C21H17ClFN3O4S/c22-18- |
InChI key | FYIBXBFDXNPBSF-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Fc1ccc(cc1Cl)S(=O)(=O)NCc |
solubility | DMSO: 5 mg/mL (clear solution) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | TCN-201 is a sulphonamide derivative, that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor. |
Biochem/physiol Actions: | TCN-201 is the first NMDA receptor antagonist that is specific for NR2A-subunit containing receptors. The pIC50 for NR2A NMDA receptors is 6.8. TCN-201has no effect on NR2B-containing receptors at concentrations up to 50 mM. |
Features and Benefits: | This compound is featured on the Glutamate Receptors (Ion Channel Family) ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H335 |
Hazard Codes | Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |