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TCN-201

SIGMA/SML0416 - ≥98% (HPLC)

Synonym: 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide

CAS Number: 852918-02-6
Empirical Formula (Hill Notation): C21H17ClFN3O4S
Molecular Weight: 461.89
MDL Number: MFCD06683895
Linear Formula: C21H17ClFN3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0416-5MG 5 mg
 $127.00
1/EA		 Add To Favorites
45-SML0416-25MG 25 mg
 $511.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
InChI key FYIBXBFDXNPBSF-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1ccc(cc1Cl)S(=O)(=O)NCc2ccc(cc2)C(=O)NNC(=O)c3ccccc3
solubility DMSO: 5 mg/mL (clear solution)
storage temp. 2-8°C
Biochem/physiol Actions: TCN-201 is a sulphonamide derivative, that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor.
Biochem/physiol Actions: TCN-201 is the first NMDA receptor antagonist that is specific for NR2A-subunit containing receptors. The pIC50 for NR2A NMDA receptors is 6.8. TCN-201has no effect on NR2B-containing receptors at concentrations up to 50 mM.
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H335
Hazard Codes Xi
Risk Statements 22-36/37/38
Safety Statements 26-36/37/39
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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