Costunolide

SIGMA/SML0417 - ≥97% (HPLC)

CAS Number: 553-21-9
Empirical Formula (Hill Notation): C₁₅H₂₀O₂
Molecular Weight: 232.32
MDL Number: MFCD00210262
Linear Formula: C₁₅H₂₀O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0417-5MG	5 mg	$127.00 1/EA		Add To Favorites
45-SML0417-25MG	25 mg	$505.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
InChI key	HRYLQFBHBWLLLL-AHNJNIBGSA-N
optical activity	[α]/D +110.0 to +130.0°, c = 0.5 in chloroform-d
Quality Level	100
SMILES string	CC1=C/CCC(C)=C[C@H]2OC(=O)C(=C)[C@@H]2CC1
solubility	DMSO: 10 mg/mL (clear solution)
storage temp.	−20°C

Application:	Costunolide has been used to study its effects in allergic asthma using female Balb/c mice and rat basophilic leukemia (RBL)-2H3 mast cells.
Biochem/physiol Actions:	Costunolide is a potent inducer of apoptosis and potent anti-cancer agent. Costunolide has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and inhibits telomerase activity.
Biochem/physiol Actions:	Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
General description:	Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280 - P302 + P352
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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