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TAPI-2 acetate salt

SIGMA/SML0420 - ≥98% (HPLC)

Synonym: N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide; Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2

CAS Number: 689284-12-6
Empirical Formula (Hill Notation): C19H37N5O5 · xC2H4O2
Molecular Weight: 415.53 (free base basis)
MDL Number: MFCD22666396
Linear Formula: C19H37N5O5 · xC2H4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0420-1MG 1 mg
 $419.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form lyophilized powder
InChI 1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25);1H3,(H,3,4)/t12-,13+,15+;/m0./s1
InChI key LMUSZKBIFGOFBD-RAFLFFCLSA-N
Quality Level 100 
shipped in wet ice
SMILES string CC(O)=O.CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
storage temp. −20°C
Application: TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.
Biochem/physiol Actions: TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).
Biochem/physiol Actions: TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.
Features and Benefits: This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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