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SB265610

SIGMA/SML0421 - ≥98% (HPLC)

Synonym: 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea; N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea; SB 265610

CAS Number: 211096-49-0
Empirical Formula (Hill Notation): C14H9BrN6O
Molecular Weight: 357.16
MDL Number: MFCD09971124
Linear Formula: C14H9BrN6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0421-5MG 5 mg
 $176.00
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45-SML0421-25MG 25 mg
 $707.00
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assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChI key SEDUMQWZEOMXSO-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
solubility DMSO: 15 mg/mL, clear
storage temp. 2-8°C
Application: SB265610 has been used:
• as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
• as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
• as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain
Biochem/physiol Actions: SB265610 is a potent and selective CXCR2 chemokine receptor antagonist.
Biochem/physiol Actions: SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
Features and Benefits: This compound is featured on the Chemokine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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