SB265610
SIGMA/SML0421 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 211096-49-0
Empirical Formula (Hill Notation): C14H9BrN6O
Molecular Weight: 357.16
MDL Number: MFCD09971124
Linear Formula: C14H9BrN6O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to light brown |
form | powder |
InChI | 1S/C14H9BrN6O/c15-9-3-1-2 |
InChI key | SEDUMQWZEOMXSO-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Brc1ccccc1NC(=O)Nc2ccc(C# |
solubility | DMSO: 15 mg/mL, clear |
storage temp. | 2-8°C |
Application: | SB265610 has been used: • as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR) • as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells • as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain |
Biochem/physiol Actions: | SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM. |
Features and Benefits: | This compound is featured on the Chemokine Receptors ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51111800 |