Caspofungin diacetate
SIGMA/SML0425 - ≥97% (HPLC)
Synonym: 1-
CAS Number: 179463-17-3
Empirical Formula (Hill Notation): C52H88N10O15 · 2C2H4O2
Molecular Weight: 1213.42
Linear Formula: C52H88N10O15 · 2C2H4O2
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C52H88N10O15.2C2H4O2/c |
InChI key | OGUJBRYAAJYXQP-IJFZAWIJSA |
Quality Level | 100 ![]() |
shipped in | wet ice |
SMILES string | CC([O-])=O.CC([O-])=O.CC[ |
solubility | H2O: 15 mg/mL (clear solution) |
storage temp. | −20°C |
Application: | Caspofungin diacetate has been used: • in an antifungal susceptibility test • as a standard antifungal for valproic acid (VPA)-synergy assessment • to treat Cryptococcus neoformans strain B3501 to study natural killer (NK) cell killing of Cryptococcus in the presence of β-1,3-glucan |
Biochem/physiol Actions: | Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall. |
Biochem/physiol Actions: | Caspofungin, aechinocandin, a lipophilic antifungal drug, and α β-1,3-D-glucan synthesis antagonist, are used in fungal cell wall biosynthesis research to study the role of β-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. Caspofungin is used to treat esophageal candidiasis, candida infections, febrile neutropenia, invasive candidiasis, and invasive aspergillosis. |
General description: | Caspofungin belongs to the echinocandins class of drugs. This drug has a limited α-phase half-life (t 1/2) of one to two hours (volume of distribution of 9.7L) and a β-phase t 1/2 of nine to 11 hours. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 51101500 |