Caspofungin diacetate

SIGMA/SML0425 - ≥97% (HPLC)

Synonym: 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0

CAS Number: 179463-17-3
Empirical Formula (Hill Notation): C₅₂H₈₈N₁₀O₁₅ · 2C₂H₄O₂
Molecular Weight: 1213.42
Linear Formula: C₅₂H₈₈N₁₀O₁₅ · 2C₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0425-5MG	5 mg	$112.00 1/EA	Add To Favorites
45-SML0425-25MG	25 mg	$451.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0425-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;21-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);21H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-;;/m0../s1
InChI key	OGUJBRYAAJYXQP-IJFZAWIJSA-N
Quality Level	100
shipped in	wet ice
SMILES string	CC([O-])=O.CC([O-])=O.CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCC[NH3+])NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c4ccc(O)cc4)[C@H](O)CC[NH3+]
solubility	H₂O: 15 mg/mL (clear solution)
storage temp.	−20°C

Application:	Caspofungin diacetate has been used: • in an antifungal susceptibility test • as a standard antifungal for valproic acid (VPA)-synergy assessment • to treat Cryptococcus neoformans strain B3501 to study natural killer (NK) cell killing of Cryptococcus in the presence of β-1,3-glucan
Biochem/physiol Actions:	Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall.
Biochem/physiol Actions:	Caspofungin, aechinocandin, a lipophilic antifungal drug, and α β-1,3-D-glucan synthesis antagonist, are used in fungal cell wall biosynthesis research to study the role of β-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. Caspofungin is used to treat esophageal candidiasis, candida infections, febrile neutropenia, invasive candidiasis, and invasive aspergillosis.
General description:	Caspofungin belongs to the echinocandins class of drugs. This drug has a limited α-phase half-life (t 1/2) of one to two hours (volume of distribution of 9.7L) and a β-phase t 1/2 of nine to 11 hours.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	51101500

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