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GSK690693

SIGMA/SML0428 - ≥98% (HPLC)

Synonym: 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol

CAS Number: 937174-76-0
Empirical Formula (Hill Notation): C21H27N7O3
Molecular Weight: 425.48
MDL Number: MFCD14105605
Linear Formula: C21H27N7O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0428-5MG 5 mg
 $212.00
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45-SML0428-25MG 25 mg
 $837.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0428-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChI key KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Quality Level 100 
SMILES string CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N
solubility DMSO: 5 mg/mL (clear solution)
storage temp. 2-8°C
Application: GSK690693 has been used in western blotting and immunoprecipitations.
Biochem/physiol Actions: 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol/GSK690693 is a protein kinase B/AKT inhibitor. GSK690693 can prevent growth and apoptosis in acute lymphoblastic leukemia cell lines.
Biochem/physiol Actions: GSK690693 is a potent pan-AKT kinase inhibitor.
Biochem/physiol Actions: GSK690693 is an ATP competitive, potent pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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