Ac-YVAD-cmk
SIGMA/SML0429 - ≥95% (HPLC)
Synonym: Ac-
CAS Number: 178603-78-6
Empirical Formula (Hill Notation): C24H33ClN4O8
Molecular Weight: 540.99
MDL Number: MFCD00237124
Linear Formula: C24H33ClN4O8
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to off-white |
form | powder |
InChI | 1S/C24H33ClN4O8/c1-12(2)2 |
InChI key | UOUBHJRCKHLGFB-DGJUNBOTSA |
Quality Level | 100 ![]() |
shipped in | wet ice |
SMILES string | CC(C)[C@H](NC(=O)[C@H](Cc |
storage temp. | −20°C |
Amino Acid Sequence: | Ac-Tyr-Val-Ala-Asp-Chloro |
Application: | Ac-YVAD-cmk has been used: • as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation • as a caspase-1 inhibitor injected to C57BL/6 mice • as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury • to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER) • as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth in vivo condition |
Biochem/physiol Actions: | Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β. |
Features and Benefits: | This compound is a featured product for Apoptosis research. Click here ![]() ![]() |
Packaging: | 1, 5 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |