PR-619
SIGMA/SML0430 - ≥95% (HPLC)
Synonym: 2,6-
CAS Number: 2645-32-1
Empirical Formula (Hill Notation): C7H5N5S2
Molecular Weight: 223.28
MDL Number: MFCD00830384
Linear Formula: C7H5N5S2
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C7H5N5S2/c8-2-13-4-1-5 |
InChI key | ZXOBLNBVNROVLC-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Nc1nc(N)c(SC#N)cc1SC#N |
solubility | DMSO: 5 mg/mL (clear solution) |
storage temp. | −20°C |
Application: | PR-619 has been used: • as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells • as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction • in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays |
Biochem/physiol Actions: | PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity. |
Packaging: | 1, 5 mg in glass bottle |
Hazard Codes | Xn |
Risk Statements | 22-37/38-41-43 |
Safety Statements | 26-36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |