Synonym: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Otenzepad
CAS Number: 102394-31-0
Empirical Formula (Hill Notation): C24H31N5O2
Molecular Weight: 421.54
MDL Number: MFCD00864743
Linear Formula: C24H31N5O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| drug control |
regulated under CDSA - not available from Sigma-Aldrich Canada |
| form |
powder |
| InChI |
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31) |
| InChI key |
UBRKDAVQCKZSPO-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24 |
| solubility |
DMSO: 5 mg/mL (clear solution; warmed) |
| storage temp. |
room temp |
| Application: |
AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats. |
| Biochem/physiol Actions: |
AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist. |
| Biochem/physiol Actions: |
AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction. |
| Features and Benefits: |
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
