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AF-DX 116

SIGMA/SML0435 - ≥98% (HPLC)

Synonym: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Otenzepad

CAS Number: 102394-31-0
Empirical Formula (Hill Notation): C24H31N5O2
Molecular Weight: 421.54
MDL Number: MFCD00864743
Linear Formula: C24H31N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0435-5MG 5 mg
 $120.00
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45-SML0435-25MG 25 mg
 $322.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0435-25MG.

 

assay ≥98% (HPLC)
color white to beige
drug control regulated under CDSA - not available from Sigma-Aldrich Canada
form powder
InChI 1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChI key UBRKDAVQCKZSPO-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
solubility DMSO: 5 mg/mL (clear solution; warmed)
storage temp. room temp
Application: AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.
Biochem/physiol Actions: AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist.
Biochem/physiol Actions: AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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