Spautin-1

SIGMA/SML0440 - ≥98% (HPLC)

Synonym: 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine; C43

CAS Number: 1262888-28-7
Empirical Formula (Hill Notation): C₁₅H₁₁F₂N₃
Molecular Weight: 271.26
MDL Number: MFCD16962292
Linear Formula: C₁₅H₁₁F₂N₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0440-5MG	5 mg	$141.00 1/EA		Add To Favorites
45-SML0440-25MG	25 mg	$557.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI key	AWIVHRPYFSSVOG-UHFFFAOYSA-N
Quality Level	100
SMILES string	FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
solubility	DMSO: 15 mg/mL (clear solution)
storage temp.	2-8°C

Application:	Spautin-1 has been used as an autophagy inhibitor: • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay
Biochem/physiol Actions:	Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Biochem/physiol Actions:	Spautin-1 is an inhibitor of autophagy.
Biochem/physiol Actions:	Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H302 - H318
Precautionary statements	P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
Hazard Codes	Xi
Risk Statements	22-41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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