Spautin-1
SIGMA/SML0440 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 1262888-28-7
Empirical Formula (Hill Notation): C15H11F2N3
Molecular Weight: 271.26
MDL Number: MFCD16962292
Linear Formula: C15H11F2N3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C15H11F2N3/c16-11-3-1- |
InChI key | AWIVHRPYFSSVOG-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | FC1=CC=C(C=C1)CNC2=C3C=C( |
solubility | DMSO: 15 mg/mL (clear solution) |
storage temp. | 2-8°C |
Application: | Spautin-1 has been used as an autophagy inhibitor: • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay |
Biochem/physiol Actions: | Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy. |
Biochem/physiol Actions: | Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H302 - H318 |
Precautionary statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
Hazard Codes | Xi |
Risk Statements | 22-41 |
Safety Statements | 26-39 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |