LUF6283
SIGMA/SML0441 - ≥95% (HPLC)
Synonym: 5-
CAS Number: 92933-48-7
Empirical Formula (Hill Notation): C8H12N2O2
Molecular Weight: 168.19
MDL Number: MFCD16620107
Linear Formula: C8H12N2O2
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C8H12N2O2/c1-2-3-4-6-5 |
InChI key | ZJTXSGLJNBAMJS-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | CCCCc1cc(n[nH]1)C(O)=O |
solubility | DMSO: 10 mg/mL (clear solution; warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | LUF6283 is a partial agonist of the hydroxy-carboxylic acid receptor 2 (HCA2; GPR109A). LUF6283 binds HCA2 with a Ki value of 0.55 mM, and an intrinsic efficacy for agonist activity of 76% of the full agonist effect of niacin. The EC50 values for niacin and LUF6283 are 0.41 and 3.1 mM, respectively. LUF6283 effectively lowers plasma lipid levels, but does not induce cutaneous flushing as observed with niacin treatment. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |