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LUF6283

SIGMA/SML0441 - ≥95% (HPLC)

Synonym: 5-Butyl-1H-Pyrazole-3-carboxylic acid

CAS Number: 92933-48-7
Empirical Formula (Hill Notation): C8H12N2O2
Molecular Weight: 168.19
MDL Number: MFCD16620107
Linear Formula: C8H12N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0441-5MG 5 mg
 $0.00
1/EA
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45-SML0441-25MG 25 mg
 $0.00
1/EA
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assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
InChI key ZJTXSGLJNBAMJS-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCCCc1cc(n[nH]1)C(O)=O
solubility DMSO: 10 mg/mL (clear solution; warmed)
storage temp. 2-8°C
Biochem/physiol Actions: LUF6283 is a partial agonist of the hydroxy-carboxylic acid receptor 2 (HCA2; GPR109A). LUF6283 binds HCA2 with a Ki value of 0.55 mM, and an intrinsic efficacy for agonist activity of 76% of the full agonist effect of niacin. The EC50 values for niacin and LUF6283 are 0.41 and 3.1 mM, respectively. LUF6283 effectively lowers plasma lipid levels, but does not induce cutaneous flushing as observed with niacin treatment.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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