ML239

SIGMA/SML0442 - ≥98% (HPLC)

Synonym: (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide

CAS Number: 1378872-36-6
Empirical Formula (Hill Notation): C₁₃H₁₀Cl₃N₃O₂
Molecular Weight: 346.60
MDL Number: MFCD23098913
Linear Formula: C₁₃H₁₀Cl₃N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0442-5MG	5 mg	$103.00 1/EA	Add To Favorites
45-SML0442-25MG	25 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
InChI key	NVEDPFICKAIHKD-NGYBGAFCSA-N
Quality Level	100
SMILES string	Clc1cc(Cl)c(OCC(=O)NN=Cc2ccc[nH]2)c(Cl)c1
solubility	DMSO: 15 mg/mL (clear solution)
storage temp.	2-8°C

Application:	ML239 has been used as a proble in cellular lipid profiling.
Biochem/physiol Actions:	ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.
Biochem/physiol Actions:	ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 + H312 + H332 - H315 - H319 - H335 - H400
Precautionary statements	P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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