SU-5402

SIGMA/SML0443 - ≥98% (HPLC)

Synonym: 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid; PF-02969207; PNU-0290908

CAS Number: 215543-92-3
Empirical Formula (Hill Notation): C₁₇H₁₆N₂O₃
Molecular Weight: 296.32
MDL Number: MFCD08235144
Linear Formula: C₁₇H₁₆N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0443-5MG	5 mg	$141.00 1/EA	Add To Favorites
45-SML0443-25MG	25 mg	$557.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0443-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow to dark orange
form	powder
InChI	1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key	JNDVEAXZWJIOKB-JYRVWZFOSA-N
Quality Level	100
SMILES string	Cc1c[nH]c(C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
solubility	DMSO: 10 mg/mL (clear solution)
storage temp.	−20°C

Application:	SU5402 has been used as a fibroblast growth factor receptor inhibitor: • in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay • to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2 • to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos • to study its effect on osteogenic markers.
Biochem/physiol Actions:	SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
Biochem/physiol Actions:	SU-5402 is a FGFR antagonist and angiogenesis inhibitor.
Biochem/physiol Actions:	SU-5402 is a FGFR antagonist; angiogenesis inhibitor.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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