Advanced Search



SU-5402

SIGMA/SML0443 - ≥98% (HPLC)

Synonym: 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid; PF-02969207; PNU-0290908

CAS Number: 215543-92-3
Empirical Formula (Hill Notation): C17H16N2O3
Molecular Weight: 296.32
MDL Number: MFCD08235144
Linear Formula: C17H16N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0443-5MG 5 mg
 $127.00
1/EA		 Add To Favorites
45-SML0443-25MG 25 mg
 $505.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0443-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0443-5MG

 

assay ≥98% (HPLC)
color light yellow to dark orange
form powder
InChI 1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key JNDVEAXZWJIOKB-JYRVWZFOSA-N
Quality Level 100 
SMILES string Cc1c[nH]c(C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
solubility DMSO: 10 mg/mL (clear solution)
storage temp. −20°C
Application: SU5402 has been used as a fibroblast growth factor receptor inhibitor:
• in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
• to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
• to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
• to study its effect on osteogenic markers.
Biochem/physiol Actions: SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
Biochem/physiol Actions: SU-5402 is a FGFR antagonist and angiogenesis inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top