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Clemastine fumarate salt

SIGMA/SML0445 - ≥98% (HPLC)

Synonym: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt; (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt; 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt; 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt; Meclastine fumarate salt; Mecloprodine

CAS Number: 14976-57-9
Empirical Formula (Hill Notation): C21H26ClNO · C4H4O4
Molecular Weight: 459.96
EC Number: 239-055-2
MDL Number: MFCD00137486
Linear Formula: C21H26ClNO · C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0445-100MG 100 mg
 $93.90
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
InChI key PMGQWSIVQFOFOQ-YKVZVUFRSA-N
optical activity [α]/D +15 to +25°, c = 1 in methanol
Quality Level 100 
SMILES string OC(=O)C=CC(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
solubility DMSO: 5 mg/mL (clear solution; warmed)
storage condition desiccated
storage temp. room temp
Application: Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.
Biochem/physiol Actions: Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.
Packaging: 100 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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