Synonym: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt; (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt; 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt; 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt; Meclastine fumarate salt; Mecloprodine
CAS Number: 14976-57-9
Empirical Formula (Hill Notation): C21H26ClNO · C4H4O4
Molecular Weight: 459.96
EC Number: 239-055-2
MDL Number: MFCD00137486
Linear Formula: C21H26ClNO · C4H4O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1 |
| InChI key |
PMGQWSIVQFOFOQ-YKVZVUFRSA-N |
| optical activity |
[α]/D +15 to +25°, c = 1 in methanol |
| Quality Level |
100  |
| SMILES string |
OC(=O)C=CC(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 |
| solubility |
DMSO: 5 mg/mL (clear solution; warmed) |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Application: |
Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo. |
| Biochem/physiol Actions: |
Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity. |
| Biochem/physiol Actions: |
Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic. |
| Features and Benefits: |
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: |
Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination. |
| Packaging: |
100 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
