3-Chloro-5-hydroxybenzoic acid
SIGMA/SML0447 - ≥97% (HPLC)
CAS Number: 53984-36-4
Empirical Formula (Hill Notation): C7H5ClO3
Molecular Weight: 172.57
MDL Number: MFCD04114327
Linear Formula: C7H5ClO3
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C7H5ClO3/c8-5-1-4(7(10 |
| InChI key | RJOLIYHZZKAIET-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1cc(Cl)cc(c1)C(O)=O |
| solubility | DMSO: 15 mg/mL (clear solution) |
| storage temp. | room temp |
| Biochem/physiol Actions: | 3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81. Stimulation of either GPR81 or GPR109a in adipose tissue leads to a similar decrease in triglyceride lipolysis. Niacin is used to treat dyslipidemia via its agonism of GPR109a, but compliance is low due to side effects (flushing and pruritus), which are associated with GPR109a agonism. 3-Chloro-5-hydroxybenzoic acid is selective for GPR81 over other GPCRs, including GPR109a. While less potent than niacin (16 vs. 0.78 μM), it has similar activity as the same dose as niacin in animal studies and should not cause the flushing that is associated with niacin. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS05, GHS07 |
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Purity | ≥97% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |