TBPB
SIGMA/SML0453 - ≥98% (HPLC)
Synonym: 1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number: 634616-95-8
Empirical Formula (Hill Notation): C25H32N4O
Molecular Weight: 404.55
MDL Number: MFCD22666590
Linear Formula: C25H32N4O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C25H32N4O/c1-19-6-2-3- |
| InChI key | CWPKTBMRVATCBL-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1ccccc1CN2CCC(CC2)N3CCC |
| solubility | DMSO: 5 mg/mL (clear solution; warmed) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. |
| Biochem/physiol Actions: | TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer’s disease and the cognitive and negative symptoms of schizophrenia. |
| Features and Benefits: | This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |