HBB2

SIGMA/SML0456 - ≥98% (HPLC)

Synonym: (1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one

CAS Number: 131359-24-5
Empirical Formula (Hill Notation): C₁₇H₁₄O₃
Molecular Weight: 266.29
MDL Number: MFCD01790784
Linear Formula: C₁₇H₁₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0456-5MG	5 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites
45-SML0456-25MG	25 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+
InChI key	YNVAHBUBGBLIEY-WGDLNXRISA-N
Quality Level	100
SMILES string	Oc1ccccc1C=CC(=O)C=Cc2ccccc2O
solubility	DMSO: 15 mg/mL (clear solution)
storage temp.	−20°C

Biochem/physiol Actions:	HBB2 is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. Also, HBB2 upregulates Hsp70 in an HSF1-dependent manner. It appears that HBB2 reacts with cysteine residues of KEAP1, which leads to activation of NRF2, and binds to Hsp90 Cys that leads to activation of HST1.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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