Dorzolamide

SIGMA/SML0468 - ≥98% (HPLC)

Synonym: (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide; 4S,6S-Dorzolamide; L-671,152; MK-507

CAS Number: 120279-96-1
Empirical Formula (Hill Notation): C₁₀H₁₆N₂O₄S₃
Molecular Weight: 324.44
MDL Number: MFCD00865636
Linear Formula: C₁₀H₁₆N₂O₄S₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0468-10MG	10 mg	$106.00 1/EA	Add To Favorites
45-SML0468-50MG	50 mg	$433.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChI key	IAVUPMFITXYVAF-XPUUQOCRSA-N
optical activity	[α]/D -25 to -35°, c = 1 in methanol
Quality Level	100
SMILES string	CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
solubility	DMSO: 5 mg/mL (clear solution, warmed)
storage temp.	room temp

Biochem/physiol Actions:	Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC₅₀ value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Biochem/physiol Actions:	Dorzolamide is a potent carbonic anhydrase II inhibitor.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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