Synonym: (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide; 4S,6S-Dorzolamide; L-671,152; MK-507
CAS Number: 120279-96-1
Empirical Formula (Hill Notation): C10H16N2O4S3
Molecular Weight: 324.44
MDL Number: MFCD00865636
Linear Formula: C10H16N2O4S3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 |
| InChI key |
IAVUPMFITXYVAF-XPUUQOCRSA-N |
| optical activity |
[α]/D -25 to -35°, c = 1 in methanol |
| Quality Level |
100  |
| SMILES string |
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |
| solubility |
DMSO: 5 mg/mL (clear solution, warmed) |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. |
| Biochem/physiol Actions: |
Dorzolamide is a potent carbonic anhydrase II inhibitor. |
| Packaging: |
10, 50 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
