4-IPP
SIGMA/SML0472 - ≥97% (HPLC)
Synonym: 4-
CAS Number: 41270-96-6
Empirical Formula (Hill Notation): C10H7IN2
Molecular Weight: 282.08
MDL Number: MFCD00234609
Linear Formula: C10H7IN2
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C10H7IN2/c11-10-6-9(12 |
| InChI key | ZTCJXHNJVLUUMR-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Ic1cc(ncn1)-c2ccccc2 |
| solubility | DMSO: 10 mg/mL (clear solution, warmed) |
| storage temp. | −20°C |
| Application: | 4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay. |
| Biochem/physiol Actions: | 4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas. |
| Biochem/physiol Actions: | 4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline. |
| Biochem/physiol Actions: | 4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |