Synonym: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
CAS Number: 403718-45-6
Empirical Formula (Hill Notation): C23H16F3N3O2S
Molecular Weight: 455.45
MDL Number: MFCD02649259
Linear Formula: C23H16F3N3O2S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32) |
| InChI key |
IFNVTSPDMUUAFY-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4 |
| solubility |
DMSO: 5 mg/mL (clear solution, warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). |
| Biochem/physiol Actions: |
Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC50 value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC50 of 3 mM. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
