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Dobesilate Calcium

SIGMA/SML0488 - ≥98% (HPLC)

Synonym: 2,5-Dihydroxybenzenesulfonic acid calcium salt; 205E; Calcium 2,5-dihydroxybenzenesulfonate; Calcium Dobesilate; Hydroquinone calcium sulfonate

CAS Number: 20123-80-2 (anhydrous)
Empirical Formula (Hill Notation): C6H5O5S · 0.5Ca
Molecular Weight: 209.20
MDL Number: MFCD00867249
Linear Formula: C6H5O5S · 0.5Ca
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0488-10MG 10 mg
 $83.90
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45-SML0488-50MG 50 mg
 $359.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
InChI key QGNBTYAQAPLTMX-UHFFFAOYSA-L
Quality Level 100 
SMILES string [Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
solubility H2O: 15 mg/mL, clear
storage temp. room temp
Application: Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
Biochem/physiol Actions: Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.
Biochem/physiol Actions: Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Biochem/physiol Actions: Dobesilate Calcium is a vasoprotectant.
Features and Benefits: This compound is featured on the Nitric Oxide Synthases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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