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Ritonavir

SIGMA/SML0491 - ≥98% (HPLC)

Synonym: A-84538; ABT-538; Abbott 84538

CAS Number: 155213-67-5
Empirical Formula (Hill Notation): C37H48N6O5S2
Molecular Weight: 720.94
MDL Number: MFCD00927142
Linear Formula: C37H48N6O5S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0491-10MG 10 mg
 $84.30
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45-SML0491-50MG 50 mg
 $341.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChI key NCDNCNXCDXHOMX-XGKFQTDJSA-N
Quality Level 100 
SMILES string O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4
solubility DMSO: 10 mg/mL (clear solution, warmed)
storage temp. room temp
Application: Ritonavir has been used:
• as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function
• as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells
• as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin
Biochem/physiol Actions: Ritonavir is an HIV protease inhibitor now used frequently as a booster of other protease inhbitors. Ritonavir inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. It has also been investigated as a possible anti-cancer agent.
Biochem/physiol Actions: Ritonavir is an HIV protease inhibitor; antiretroviral.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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