Ritonavir

SIGMA/SML0491 - ≥98% (HPLC)

Synonym: A-84538; ABT-538; Abbott 84538

CAS Number: 155213-67-5
Empirical Formula (Hill Notation): C₃₇H₄₈N₆O₅S₂
Molecular Weight: 720.94
MDL Number: MFCD00927142
Linear Formula: C₃₇H₄₈N₆O₅S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0491-10MG	10 mg	$90.40 1/EA		Add To Favorites
45-SML0491-50MG	50 mg	$366.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChI key	NCDNCNXCDXHOMX-XGKFQTDJSA-N
Quality Level	100
SMILES string	O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4
solubility	DMSO: 10 mg/mL (clear solution, warmed)
storage temp.	room temp

Application:	Ritonavir has been used: • as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function • as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells • as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin
Biochem/physiol Actions:	Ritonavir is an HIV protease inhibitor now used frequently as a booster of other protease inhbitors. Ritonavir inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. It has also been investigated as a possible anti-cancer agent.
Biochem/physiol Actions:	Ritonavir is an HIV protease inhibitor; antiretroviral.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 + H312 + H332
Precautionary statements	P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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