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T16Ainh-A01

SIGMA/SML0493 - ≥95% (HPLC)

Synonym: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide

CAS Number: 552309-42-9
Empirical Formula (Hill Notation): C19H20N4O3S2
Molecular Weight: 416.52
MDL Number: MFCD03278952
Linear Formula: C19H20N4O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0493-10MG 10 mg
 $81.10
1/EA		 Add To Favorites
45-SML0493-50MG 50 mg
 $329.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
InChI key QSIYTNYMBWYHAA-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. room temp
Application: T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).
Biochem/physiol Actions: T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
Biochem/physiol Actions: T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor...
Features and Benefits: This compound is featured on the Chloride Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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