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CORM-3

SIGMA/SML0496

Synonym: Carbon monoxide releasing molecule 3; Tricarbonylchloro(glycinato)ruthenium (II)

CAS Number: 475473-26-8
Empirical Formula (Hill Notation): C5H4ClNO5Ru
Molecular Weight: 294.61
Linear Formula: C5H4ClNO5Ru
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0496-10MG 10 mg
 $136.00
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45-SML0496-50MG 50 mg
 $546.00
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color white to beige
form powder
InChI 1S/C2H5NO2.3CO.ClH.Ru/c3-1-2(4)5;3*1-2;;/h1,3H2,(H,4,5);;;;1H;/q;;;;;+2/p-2
InChI key BICHHHDSEZXKNN-UHFFFAOYSA-L
Quality Level 100 
shipped in wet ice
SMILES string [Ru+2].[Cl-].NCC(=O)[O-].O=[C].O=[C].O=[C]
solubility H2O: 20 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H2O2-induced apoptosis using primary rabbit lens epithelial cells.
Biochem/physiol Actions: CO possesses anti apoptotic function and offers protection against oxidative damage, promoting endothelial healing. CORM-3 is known to have therapeutic effects in transplantation, myocardial infarction and rheumatoid arthritis.
Biochem/physiol Actions: CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.
Biochem/physiol Actions: CORM-3 is a water-soluble carbon monoxide releasing molecule.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352200

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