BQCA
SIGMA/SML0497 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 338747-41-4
Empirical Formula (Hill Notation): C18H15NO4
Molecular Weight: 309.32
MDL Number: MFCD01315710
Linear Formula: C18H15NO4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C18H15NO4/c1-23-13-8-6 |
| InChI key | BZBBTGCKPRSPGF-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(CN2C=C(C(O)=O)C(= |
| solubility | DMSO: 10 mg/mL (clear solution) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. It potentiates M1 activity in in vitro and in vivo assays and is orally bioavailable. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer’s disease and the cognitive and negative symptoms of schizophrenia. BQCA has been shown to improve performance in cognition tasks and increase cerebral blood flow. |
| Biochem/physiol Actions: | BQCA is a potent, selective Muscarinic M1 receptor positive allosteric modulator |
| Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |