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NCTT-956

SIGMA/SML0499 - ≥97% (NMR)

Synonym: N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide

CAS Number: 438575-88-3
Empirical Formula (Hill Notation): C17H15N3O4S
Molecular Weight: 357.38
MDL Number: MFCD02228855
Linear Formula: C17H15N3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0499-5MG 5 mg
 $113.00
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assay ≥97% (NMR)
color light orange to dark orange
form powder
InChI 1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
InChI key DEXNORPUTBBNSC-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O
solubility DMSO: 5 mg/mL (clear solution)
storage temp. 2-8°C
Biochem/physiol Actions: NCTT-956 is a potent, specific 12-LO inhibitor.
Biochem/physiol Actions: NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.
Packaging: 5, 25 mg in glass bottle
Purity ≥97% (NMR)
Storage Temp. 2-8°C
UNSPSC 51111800

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