SB-590885

SIGMA/SML0501 - ≥98% (HPLC)

Synonym: 5-(2-(4-(2-Dimethylaminoethoxy)phenyl)-5-(4-pyridinyl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

CAS Number: 405554-55-4
Empirical Formula (Hill Notation): C₂₇H₂₇N₅O₂
Molecular Weight: 453.54
MDL Number: MFCD16038645
Linear Formula: C₂₇H₂₇N₅O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0501-5MG	5 mg	$180.00 1/EA	Add To Favorites
45-SML0501-25MG	25 mg	$723.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24-
InChI key	MLSAQOINCGAULQ-QLTSDVKISA-N
Quality Level	100
SMILES string	CN(C)CCOc1ccc(cc1)-c2nc(-c3ccc4c(CCC4=NO)c3)c([nH]2)-c5ccncc5
solubility	DMSO: 2 mg/mL (clear solution, warmed)
storage temp.	2-8°C

Application:	SB-590885 has been used as a component of a mixture to maintain naive human pluripotent stem cells (PSCs).It has also been used as B-Raf (BRAF) inhibitor to study its effects on lung adenocarcinoma cell lines.
Biochem/physiol Actions:	SB-590885 is a potent and selective ATP competitive inhibitor of B-Raf kinase with Kd = 300 pM for B-Raf, and >1000-fold selectivity over a panel of 22 commonly studied cellular kinases
Biochem/physiol Actions:	SB-590885 is a potent and selective B-Raf kinase inhibitor.
Features and Benefits:	This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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