Synonym: LSN-411575; LY 411575; N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
CAS Number: 209984-57-6
Empirical Formula (Hill Notation): C26H23F2N3O4
Molecular Weight: 479.48
MDL Number: MFCD09832551
Linear Formula: C26H23F2N3O4
Product Type: Chemical
| assay |
≥97% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1 |
| InChI key |
ULSSJYNJIZWPSB-CVRXJBIPSA-N |
| Quality Level |
100  |
| shipped in |
wet ice |
| SMILES string |
C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24 |
| solubility |
DMSO: 5 mg/mL, clear |
| storage temp. |
−20°C |
| Application: |
LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor. |
| Biochem/physiol Actions: |
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation. |
| Biochem/physiol Actions: |
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ40/42 after acute or chronic treatment, and blocks Notch activation. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥97% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
