Synonym: 4,5,6,7-Tetrahydro-5,5,7,7-tetramethyl-2-[[(5-nitro-2-thienyl)carbonyl]amino]-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester; NPC-26
CAS Number: 864860-32-2
Empirical Formula (Hill Notation): C19H23N3O5S2
Molecular Weight: 437.53
MDL Number: MFCD04428321
Linear Formula: C19H23N3O5S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
light orange to dark orange |
| form |
powder |
| InChI |
1S/C19H23N3O5S2/c1-6-27-17(24)13-10-9-18(2,3)21-19(4,5)14(10)29-16(13)20-15(23)11-7-8-12(28-11)22(25)26/h7-8,21H,6,9H2,1-5H3,(H,20,23) |
| InChI key |
DWGSXNATVAGHKZ-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CCOC(=O)c1c2CC(C)(C)NC(C)(C)c2sc1NC(=O)c3ccc(s3)[N+]([O-])=O |
| solubility |
DMSO: 2 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells, similar to erastin. The effects of NPC26 are independent of ROS scavengers, which can block cell death induced by erastin. |
| Biochem/physiol Actions: |
NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
