Pentostatin

SIGMA/SML0508 - ≥95% (HPLC)

Synonym: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; 2′-dCF; DCF; Deoxycoformycin

CAS Number: 53910-25-1
Empirical Formula (Hill Notation): C₁₁H₁₆N₄O₄
Molecular Weight: 268.27
Linear Formula: C₁₁H₁₆N₄O₄
Product Type: Chemical

assay	≥95% (HPLC)
color	white to beige
form	powder
InChI	1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChI key	FPVKHBSQESCIEP-JQCXWYLXSA-N
optical activity	[α]/D +70 to +80°, c = 1 in H₂O
Quality Level	100
shipped in	wet ice
SMILES string	OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23
solubility	H₂O: 10 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Application:	Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.
Biochem/physiol Actions:	Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Biochem/physiol Actions:	Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).
Biochem/physiol Actions:	Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.
Features and Benefits:	This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes:	Air sensitve; hygroscopic.
Packaging:	5, 25 mg in glass bottle