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S 26948

SIGMA/SML0510 - ≥98% (HPLC)

Synonym: 2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester; S26948

CAS Number: 353280-43-0
Empirical Formula (Hill Notation): C28H25NO7S
Molecular Weight: 519.57
MDL Number: MFCD18086885
Linear Formula: C28H25NO7S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0510-5MG 5 mg
 $136.00
1/EA		 Add To Favorites
45-SML0510-25MG 25 mg
 $532.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3
InChI key NSMJEHGOMXSLCW-UHFFFAOYSA-N
Quality Level 100 
SMILES string COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC
solubility DMSO: 10 mg/mL (clear solution)
storage temp. 2-8°C
Biochem/physiol Actions: S 26948 belongs to the non-thiazolidinedione (TZD) class of drugs. It has the potential to treat diabetes and atherogenesis.
Biochem/physiol Actions: S 26948 is a partial PPARγ agonist; selective PPARγ modulator (SPPARγM).
Biochem/physiol Actions: S 26948 is a selective PPARγ modulator (SPPARγM). S 26948 is as effective as rosiglitazone in reducing insulin resistance and lipid homeostasis, but does not increase body or white adipose tissue weight. S 26948 also leads to different co-activatior recruitment to PPARγ than rosiglitazone.
Features and Benefits: This compound is featured on the Nuclear Receptors (Non-Steroids)  and Nuclear Receptors (PPARs)  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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