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ML 210

SIGMA/SML0521 - ≥98% (HPLC)

Synonym: CID 49766530; ML-210; [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

CAS Number: 1360705-96-9
Empirical Formula (Hill Notation): C22H20Cl2N4O4
Molecular Weight: 475.32
MDL Number: MFCD22666407
Linear Formula: C22H20Cl2N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0521-5MG 5 mg
 $140.00
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45-SML0521-25MG 25 mg
 $519.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
InChI key VIBHJPDPEVVDTB-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1onc(C(=O)N2CCN(CC2)C(c3ccc(Cl)cc3)c4ccc(Cl)cc4)c1[N+]([O-])=O
storage temp. 2-8°C
Application: ML 210 has been used as a glutathione peroxidase 4 (GPX4) inhibitor to induce ferroptosis in cancer cells. It has also been used as a GPX4 inhibitor to examine whether pharmacological inhibition of GPX4 altered prominin2 expression and impacted ferroptosis in adherent MCF10A and Hs578t cells.
Biochem/physiol Actions: ML 210 acts as a selenoenzyme glutathione peroxidase 4 (GPX4) inhibitor. It exhibits cytotoxicity against few ovarian cancer cell lines.
Biochem/physiol Actions: ML 210 induces cell death in RAS expressing tumor cells.
Biochem/physiol Actions: ML 210 induces non-apoptotic cell death in tumor cells expressing the RAS oncogene.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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