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JM6

SIGMA/SML0522 - ≥97% (HPLC)

Synonym: 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole; 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide

CAS Number: 1008119-83-2
Empirical Formula (Hill Notation): C23H26N4O6S2
Molecular Weight: 518.61
MDL Number: MFCD22380618
Linear Formula: C23H26N4O6S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0522-5MG 5 mg
 $138.00
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assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
InChI key AOZLMMDVJOGGEQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1ccc(cc1OC)S(=O)(=O)Nc2nc(c(CN3CCCCC3)s2)-c4cccc(c4)[N+]([O-])=O
solubility DMSO: 2 mg/mL (clear solution, warmed)
storage temp. 2-8°C
Biochem/physiol Actions: JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease.
Biochem/physiol Actions: JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO); Ro 61-8048 analog.
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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