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ML277

SIGMA/SML0524 - ≥98% (HPLC)

Synonym: (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide; (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide; CID-53347902; VU0458298-2, VU0458298-3

CAS Number: 1401242-74-7
Empirical Formula (Hill Notation): C23H25N3O4S2
Molecular Weight: 471.59
MDL Number: MFCD23704792
Linear Formula: C23H25N3O4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0524-5MG 5 mg
 $146.00
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45-SML0524-25MG 25 mg
 $577.00
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This image depicts SML0524-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-20(26)22(27)25-23-24-15-21(31-23)17-8-10-18(30-2)11-9-17/h6-13,15,20H,3-5,14H2,1-2H3,(H,24,25,27)/t20-/m1/s1
InChI key UKSXJENCMIVQMU-HXUWFJFHSA-N
Quality Level 100 
SMILES string COc1ccc(cc1)-c2cnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c4ccc(C)cc4)s2
solubility DMSO: 5 mg/mL, clear
storage temp. 2-8°C
Application: ML277 has been used as the KCNQ1 activator to treat cells in lung metastasis assay.
Biochem/physiol Actions: ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.
Biochem/physiol Actions: ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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