kb-NB142-70

SIGMA/SML0525 - ≥97% (HPLC)

Synonym: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

CAS Number: 1233533-04-4
Empirical Formula (Hill Notation): C₁₁H₉NO₂S₂
Molecular Weight: 251.32
MDL Number: MFCD18086915
Linear Formula: C₁₁H₉NO₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0525-5MG	5 mg	$159.00 1/EA		Add To Favorites
45-SML0525-25MG	25 mg	$626.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
InChI key	DHUAGGSHTKPOHU-UHFFFAOYSA-N
Quality Level	100
SMILES string	Oc1ccc2sc3C(=O)NCCSc3c2c1
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC₅₀ for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.
Biochem/physiol Actions:	kb-NB142-70 is a protein kinase D (PKD1) inhibitor.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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