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EHop-016

SIGMA/SML0526 - ≥98% (HPLC)

Synonym: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine

CAS Number: 1380432-32-5
Empirical Formula (Hill Notation): C25H30N6O
Molecular Weight: 430.55
MDL Number: MFCD23143628
Linear Formula: C25H30N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0526-5MG 5 mg
 $113.00
1/EA		 Add To Favorites
45-SML0526-25MG 25 mg
 $453.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)
InChI key AFTZZRFCMOAFCR-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCn1c2ccccc2c3cc(Nc4ccnc(NCCCN5CCOCC5)n4)ccc13
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: EHop-016 has been used as the EHop inhibitor to study signalling diversity during Chlamydia trachomatis cell entry. It has also been used as a RAC inhibitor.
Biochem/physiol Actions: EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. EHop-016 inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation.
Biochem/physiol Actions: EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GTP Binding Proteins (Low Molecular Weight)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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